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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 106, No. 1, 2011, pp. 51-55
Bioline Code: oc11008
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 106, No. 1, 2011, pp. 51-55

 en High vancomycin resistance among biofilms produced by Staphylococcus check for this species in other resources species isolated from central venous catheters
Antunes, Ana Lúcia Souza; Bonfanti, Jéssica Weis; Perez, Leandro Reus Rodrigues; Pinto, Camille Cattani Ferreira; de Freitas, Ana Lúcia Peixoto; Macedo, Alexandre José & Barth, Afonso Luis

Abstract

Biofilm production is an important mechanism that allows microbes to escape host defences and antimicrobial therapy. Vancomycin has been used largely for the treatment of methicillin-resistant staphylococcal infections. Here, we determined the minimal inhibitory concentration (MIC) and minimal biofilm eradication concentration (MBEC) for 82 Staphylococcus check for this species in other resources species isolated from central venous catheters (CVC). Our results showed that the 41 strong and moderate-biofilm-producing isolates presented a higher MBEC/MIC ratio for vancomycin than the 24 weak-biofilm-producing isolates, illustrating the importance of biofilm production ability and the difficulty in treating biofilm-related infections. The MBEC was significantly higher in moderate-biofilm-producing isolates than in weak-biofilm-producing isolates (p < 0.001) and in strong-biofilm-producing isolates than in weak-biofilm-producing isolates (p = 0.001). The correlation between the MIC and the MBEC was poor. Based on our results, we recommend that bacterial biofilms be suspected in all cases of CVC infection.

Keywords
biofilm - vancomycin - Staphylococcus spp

 
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