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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 106, No. 2, 2011, pp. 207-211
Bioline Code: oc11034
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 106, No. 2, 2011, pp. 207-211

 en Leishmania infection in humans, dogs and sandflies in a visceral leishmaniasis endemic area in Maranhão, Brazil
Felipe, Ilana Mirian Almeida; de Aquino, Dorlene Maria Cardoso; Kuppinger, Oliver; Santos, Max Diego Cruz; Rangel, Maurício Eduardo Salgado; Barbosa, David Soeiro; Barral, Aldina; Werneck, Guilherme Loureiro & de Jesus Mendes Caldas, Arlene

Abstract

Leishmania infection in humans, dogs and sandflies was examined in the endemic visceral leishmaniasis (VL) municipality of Raposa, state of Maranhão, Brazil. In this study, we examined Leishmania chagasi check for this species in other resources infection in the blood serum of both humans and Canis familiaris check for this species in other resources and the natural Leishmania check for this species in other resources sp. infection rate in the sandfly vector, Lutzomyia longipalpis check for this species in other resources . Enzyme-linked immunosorbent assay, indirect immunofluorescence reaction and polymerase chain reaction were performed to detect Leishmania infections in humans, dogs and sandflies, respectively. Overall, 186 out of 986 studied human beings were infected with L. chagasi parasites, representing an infection prevalence of 18.9%. An even higher infection rate was detected in dogs, where 66 (47.8%) out of 138 were infected. Among all Lu. longipalpis captured (n = 1,881), only 26.7% were females. The Leishmania infection frequency for the vector Lu. longipalpis was 1.56%. Remarkably, all infected sandflies were found in the peridomiciliary area. Furthermore, a high incidence of asymptomatic forms of VL in the human and canine populations was observed. The results of this study suggest autochthonous transmission of L. chagasi in this endemic area for visceral leishmaniasis because infection by Leishmania sp. was identified in all important elements of the transmission chain

Keywords
serum prevalence - Lutzomyia longipalpis - visceral leishmaniasis - Maranhão - Brazil

 
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