Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
Vol. 106, No. 2, 2011, pp. 220-226
Bioline Code: oc11036
Full paper language: English
Document type: Research Article
Document available free of charge
Memórias do Instituto Oswaldo Cruz, Vol. 106, No. 2, 2011, pp. 220-226
© Copyright © 2011 - Instituto Oswaldo Cruz - Fiocruz
Polymorphism analysis of the CTLA-4 gene in paracoccidioidomycosis patients|
Lozano, Viviane F.; Lins, Tulio C.; Teixeira, Marcus M.; Vieira, Rodrigo G.; Blotta, Maria Heloisa S.L.; Goes, Alfredo M.; Silva, Izabel Cristina R.; Pereira, Rinaldo W.; Bocca, Anamelia L. & Felipe, Maria Sueli S.
The CTLA-4 protein is expressed in activated T cells and plays an essential role in the immune response through its regulatory effect on T cell activation. Polymorphisms of the CTLA-4 gene have been correlated with autoimmune, neoplastic and infectious illnesses. This work aimed to verify possible associations between single nucleotide polymorphisms (SNPs) in CTLA-4, -318C/T in the promoter and +49A/G in exon 1 and paracoccidioidomycosis (PCM) caused by Paracoccidioides brasiliensis. For this purpose, 66 chronic form PCM patients and 76 healthy controls had their allele, genotype and haplotype frequencies determined. The genetic admixture structure of the patients and controls was evaluated to eliminate ancestral bias. The comparison of frequencies indicated no significant differences between patients and controls that could link the SNPs to PCM. Groups were admixture matched with no difference observed in population ancestry inference, indicating that the absence of association between CTLA-4 polymorphisms and PCM could not be attributed to ancestral bias. This study showed that there was no association between the CTLA-4 SNPs -318 and +49 and the resistance or susceptibility to PCM.
admixture - Brazilian population - haplotypes - Paracoccidioides brasiliensis - PCM - single nucleotide polymorphism
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