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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060 EISSN: 1678-8060
Vol. 106, No. 3, 2011, pp. 285-292
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Bioline Code: oc11048
Full paper language: English
Document type: Research Article
Document available free of charge
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Memórias do Instituto Oswaldo Cruz, Vol. 106, No. 3, 2011, pp. 285-292
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Genetic and biological characterization of a densovirus isolate that affects dengue virus infection
Mosimann, Ana Luiza Pamplona; Bordignon, Juliano; Mazzarotto, Giovanny Camacho Antevêre; Motta, Maria Cristina M.; Hoffmann, Federico & dos Santos, Claudia Nunes Duarte
Abstract
Brevidensoviruses have an encapsidated, single-stranded DNA genome that predominantly has a negative polarity. In recent years, they have received particular attention due to their potential role in the biological control of pathogenic arboviruses and to their unnoticed presence in cell cultures as contaminants. In addition, brevidensoviruses may also be useful as viral vectors. This study describes the first genetic and biological characterization of a mosquito densovirus that was isolated in Brazil; moreover, we examined the phylogenetic relationship between this isolate and the other brevidensoviruses. We further demonstrate that this densovirus has the potential to be used to biologically control dengue virus (DENV) infection with in vitro co-infection experiments. The present study provides evidence that this densovirus isolate is a fast-spreading virus that affects cell growth and DENV infection.
Keywords
densovirus - Brevidensovirus - biological control - dengue virus
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