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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 106, No. 4, 2011, pp. 395-498
Bioline Code: oc11083
Full paper language: English
Document type: Short Communication
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 106, No. 4, 2011, pp. 395-498

 en Full-length genomic sequence of hepatitis B virus genotype C2 isolated from a native Brazilian patient
Alvarado-Mora, Mónica Viviana; Santana, Rúbia Anita Ferraz; Sitnik, Roberta; Ferreira, Paulo Roberto Abrão; Mangueira, Cristovão Luís Pitangueira; Carrilho, Flair José & Pinho, João Renato Rebello

Abstract

The hepatitis B virus (HBV) is among the leading causes of chronic hepatitis, cirrhosis and hepatocellular carcinoma. In Brazil, genotype A is the most frequent, followed by genotypes D and F. Genotypes B and C are found in Brazil exclusively among Asian patients and their descendants. The aim of this study was to sequence the entire HBV genome of a Caucasian patient infected with HBV/C2 and to infer the origin of the virus based on sequencing analysis. The sequence of this Brazilian isolate was grouped with four other sequences described in China. The sequence of this patient is the first complete genome of HBV/C2 reported in Brazil.

Keywords
hepatitis B virus, genotype C2, China, Bayesian analyses, complete genome, Brazilian patient

 
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