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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 106, No. 5, 2011, pp. 617-619
Bioline Code: oc11103
Full paper language: English
Document type: Short Communication
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 106, No. 5, 2011, pp. 617-619

 en Lower production of IL-17A and increased susceptibility to Mycobacterium bovis check for this species in other resources in mice coinfected with Strongyloides venezuelensis check for this species in other resources
Dias,Alyria Teixeira; de Castro, Sandra Bertelli Ribeiro; Alves, Caio César Souza; Rezende, Alice Belleigoli; Rodrigues, Michele Fernandes; Machado, Rachel Rocha Pinheiro; Fernandes, Adriana; Corrêa, Deborah Negrão; Teixeira, Henrique Couto & Ferreira, Ana Paula

Abstract

The presence of intestinal helminths can down-regulate the immune response required to control mycobacterial infection. BALB/c mice infected with Mycobacterium bovis following an infection with the intestinal helminth Strongyloides venezuelensis showed reduced interleukin-17A production by lung cells and increased bacterial burden. Also, small granulomas and a high accumulation of cells expressing the inhibitory molecule CTLA-4 were observed in the lung. These data suggest that intestinal helminth infection could have a detrimental effect on the control of tuberculosis (TB) and render coinfected individuals more susceptible to the development of TB.

Keywords
M. bovis, S. venezuelensis, coinfection, IL-17, CTLA-4, tuberculosis

 
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