Ocular toxoplasmosis can result in recurrent uveitis. Studies have shown that a correlation between active ocular toxoplasmosis and the presence of anti- Toxoplasma gondii
secretory IgA (SIgA) in tears. This study compares anti-T. gondii
SIgA levels in patients' tears during the acute and inactive phases of toxoplasmic uveitis
. Twenty-nine positive tear specific SIgA for T. gondii
patients with acute toxoplasmic uveitis were selected and were followed-up for at least two years, when the anti-T. gondii SIgA tears levels were determined. Specific SIgA for T. gondii
was negative in 22 patients (75.86%) and positive in seven patients (24.13%) of whom six (85.7%) were followed over three years. Average SIgA levels during the acute phase are 1.54 and decrease significantly to 0.72 (p = 0.0001) during the inactive phase of disease. Because anti-T. gondii
SIgA in the tear is negative in 75.86% of patients after the acute phase of infection, T. gondii
SIgA levels may be used as a complementary diagnostic marker for active ocular toxoplasmosis.