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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 106, No. 5, 2011, pp. 629-631
Bioline Code: oc11106
Full paper language: English
Document type: Short Communication
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 106, No. 5, 2011, pp. 629-631

 en Genotyping of two Neisseria gonorrhoeae check for this species in other resources fluroquinolone-resistant strains in the Brazilian Amazon Region
Ferreira, William Antunes; Ferreira, Cristina Motta; Naveca, Felipe Gomes; Almeida, Nayanne Cristina Oliveira da Silva; Vasconcelos, Waldemara de Souza; Gomes, Jairo de Souza; da Silva, Maria de Fátima Pinto & Alecrim, Maria das Graças Costa

Abstract

We report two ciprofloxacin and ofloxacin-resistant Neisseria gonorrhoeae strains that were isolated from the urethral discharge of male patients at the sexually transmitted diseases outpatient clinic of the Alfredo da Matta Foundation (Manaus, state of Amazonas, Brazil). The gonococci displayed minimal inhibitory concentrations (> 32.00 µg/mL) and three mutations in the quinolone resistance-determining region (S91F and D95G in GyrA and S87R in ParC). Both isolates were genotyped using N. gonorrhoeae multi-antigen sequence typing and the analysis showed that the ST225 which represented an emerging widespread multi-resistant clone that has also been associated with reduced susceptibility to ceftriaxone. We recommend continued surveillance of this pathogen to assess the efficacy of anti-gonococcal antibiotics in Brazil.

Keywords
Neisseria gonorrhoeae, fluroquinolone resistance, gyrA and parC, genotyping, MAST

 
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