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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 106, No. 6, 2011, pp. 701-704
Bioline Code: oc11119
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 106, No. 6, 2011, pp. 701-704

 en Interaction of Trichomonas vaginalis check for this species in other resources and Tritrichomonas foetus check for this species in other resources with keratin: an important role in parasite infection
Vilela, Ricardo & Benchimol, Marlene

Abstract

Trichomonas vaginalis check for this species in other resources and Tritrichomonas foetus check for this species in other resources are human and bovine parasites, respectively, that provoke the sexually transmitted disease trichomoniasis. These extracellular parasites adhere to the host epithelial cell surface. Although mucinases and proteases have been described as important proteins for parasite adhesion to epithelial cells, no studies have examined the role of the keratin molecules that cornify the vaginal epithelium. Here, we investigated the interaction of T. vaginalis and T. foetus with human keratin in vitro; additionally, adherence assays were performed in cattle with T. foetus to elucidate whether trichomonads were able to interact with keratin in vivo. We demonstrated that both T. vaginalis and T. foetus interacted directly with keratin. Additionally, the trichomonads ingested and digested keratin, shedding new light on the Trichomonas infection process.

Keywords
Trichomonas vaginalis, Tritrichomonas foetus, endocytosis, keratin, parasite-cell interaction

 
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