search
for
 About Bioline  All Journals  Testimonials  Membership  News  Donations


Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 106, No. 6, 2011, pp. 725-730
Bioline Code: oc11122
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 106, No. 6, 2011, pp. 725-730

 en Genotypes of Cryptococcus neoformans check for this species in other resources and Cryptococcus gattii check for this species in other resources as agents of endemic cryptococcosis in Teresina, Piauí (northeastern Brazil)
Martins, Liline; Wanke, Bodo; Lazéra, Márcia; Trilles, Luciana; Barbosa, Gláucia; Macedo, Regina; Cavalcanti, Maria; Eulálio, Kelsen; Castro, José; Silva, Adalberto; Nascimento, Fernando; Gouveia, Viviane & Monte, Semiramis

Abstract

Throughout Brazil, Cryptococcus neoformans check for this species in other resources is the cause of cryptococcosis, whereas Cryptococcus gattii check for this species in other resources is endemic to the northern and northeastern states. In this study, the molecular types of 63 cryptococcal isolates recovered from the cerebrospinal fluid of meningitis patients diagnosed between 2008-2010 in Teresina, Piauí, Brazil, were analysed. Out of the 63 patients, 37 (58.7%) were human immunodeficiency virus (HIV)-positive and 26 (41.3%) were HIV-negative. URA5-restriction fragment length polymorphism analysis identified 37/63 (58.7%) isolates as the C. neoformans VNI genotype, predominantly in HIV-positive patients (32/37, 86.5%), and 24/63 (38.1%) as the C. gattii VGII genotype, mostly in HIV-negative patients (21/26, 80.8%). The occurrence of C. gattii VGII in six apparently healthy children and in seven adolescents/young adults in this region reaffirms the endemic occurrence of C. gattii VGII-induced primary cryptococcosis and early cryptococcal infection. Lethality occurred in 18/37 (48.6%) of the HIV-positive subjects and in 13/26 (50%) of the HIV-negative patients. Our results provide new information on the molecular epidemiology of C. neoformans and C. gattii in Brazilian endemic areas.

Keywords
Cryptococcus gattii, Cryptococcus neoformans, genotypes, endemic mycoses, children, immunocompetent host

 
© Copyright © 2011 - Instituto Oswaldo Cruz - Fiocruz
Alternative site location: http://memorias.ioc.fiocruz.br

Home Faq Resources Email Bioline
© Bioline International, 1989 - 2017, Site last up-dated on 05-Dec-2017.
Site created and maintained by the Reference Center on Environmental Information, CRIA, Brazil
System hosted by the Internet Data Center of Rede Nacional de Ensino e Pesquisa, RNP, Brazil