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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 106, No. 8, 2011, pp. 1045-1048
Bioline Code: oc11203
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 106, No. 8, 2011, pp. 1045-1048

 en Cotrimoxazole enhances the in vitro susceptibility of Coccidioides posadasii check for this species in other resources to antifungals
Cordeiro, Rossana de Aguiar; Astete-Medrano, Delia Jessica; Marques, Francisca Jakelyne de Farias; Andrade, Heuziwanne Tavares Leite; Neto, Lauro Vieira Perdigão; Tavares, Juliane Lira; de Lima, Rita Amanda Chaves; Patoilo, Kharla Kharolyni Nobre Rabelo; Monteiro, Andre Jalles; Brilhante, Raimunda Sâmia Nogueira; Rocha, Marcos Fábio Gadelha; de Camargo, Zoilo Pires & Sidrim, José Júlio Costa

Abstract

The aim of the present study was to evaluate the effect of cotrimoxazole on the in vitro susceptibility of Coccidioides posadasii check for this species in other resources strains to antifungals. A total of 18 strains of C. posadasii isolated in Brazil were evaluated in this study. The assays were performed in accordance with the Clinical and Laboratory Standards Institute guidelines and the combinations were tested using the checkerboard method. The minimum inhibitory concentrations were reduced by 11, 2.4, 4.3 and 3.5 times for amphotericin B, itraconazole, fluconazole and voriconazole, respectively. Moreover, it was seen that cotrimoxazole itself inhibited C. posadasii strains in vitro. The impairment of folic acid synthesis may be a potential antifungal target for C. posadasii.

Keywords
Coccidioides posadasii - cotrimoxazole - antifungals - susceptibility - antimicrobial synergism

 
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