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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 106, No. 8, 2011, pp. 1052-1054
Bioline Code: oc11205
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 106, No. 8, 2011, pp. 1052-1054

 en Vaxcine™: an oil-based adjuvant for influenza vaccines
Alves, Rosely Cabette Barbosa; New, Roger Randal Charles; Andrade, Gabrielle Ribeiro; Mendonça, Rita Maria Zucatelli; Sant’Anna, Osvaldo Augusto Brasil Esteves; Mancini, Dalva Assunção Portari; da Silva-Junior, Silvio Marciano & Domingos, Marta de Oliveira

Abstract

Vaccination is the method of choice for the prevention of influenza infection. However, the quantity of the antigen available, especially in the case of pandemics, often fails to meet the global demand. However, improved adjuvants can overcome this problem. Preliminary results obtained in this study revealed that one year after a single subcutaneous immunisation with influenza A H3N2 virus in an oil-based carrier, Vaxcine™, outbreed mice produced a high immunoglobulin G response that lasted for up to one year and exhibited less variation in titre compared with the response of the control group treated with alum. The haemagglutination-inhibition titres induced by Vaxcine™ were also higher than those generated by alum. These data indicate that Vaxcine™ is a good adjuvant candidate for seasonal influenza vaccines.

Keywords
Vaxcine™ - adjuvant - influenza - vaccine

 
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