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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 106, No. 8, 2011, pp. 1055-1057
Bioline Code: oc11206
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 106, No. 8, 2011, pp. 1055-1057

 en The activity of a metronidazole analogue and its β-cyclodextrin complex against Trypanosoma cruzi check for this species in other resources
Lopes, Marcela Silva; Sales Júnior, Policarpo Ademar; Lopes, Amanda Gervásio Ferreira; Yoshida, Maria Irene; da Silva, Thais Horta Alvares; Romanha, Alvaro José; Alves, Ricardo José & de Oliveira, Renata Barbosa

Abstract

In this study we prepared an inclusion complex between an iodide analogue of metronidazole (MTZ-I) and cyclodextrin (CD) to develop a safer and more effective method of treating Trypanosoma cruzi check for this species in other resources infections. According to our results, MTZ-I and MTZ-I:β-CD were 10 times more active than MTZ, demonstrating that the presence of an iodine atom on the side chain increased the trypanocidal activity while maintaining its cytotoxicity. The selective index shows that MTZ-I was 10 times more active against T. cruzi than it was against mammalian cells. The modification of MTZ side chains provides a promising avenue for the development of new drugs.

Keywords
nitroaromatic - cyclodextrin - Chagas disease - Trypanosoma cruzi

 
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