Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
Vol. 107, No. 1, 2012, pp. 125-128
Bioline Code: oc12017
Full paper language: English
Document type: Research Article
Document available free of charge
Memórias do Instituto Oswaldo Cruz, Vol. 107, No. 1, 2012, pp. 125-128
© Copyright 2012 - Memorias do Instituto Oswaldo Cruz
First detection of Rio Negro virus (Venezuelan equine encephalitis complex subtype VI) in Córdoba, Argentina|
Pisano, María Belén; Spinsanti, Lorena Ivana; Díaz, Luis Adrián; Farías, Adrián Alejandro; Almirón, Walter Ricardo; Ré, Viviana Elizabeth & Contigiani, Marta Silvia
Rio Negro virus (RNV) (Venezuelan equine encephalitis subtype VI) circulates only in Argentina; in northern provinces, isolates have been obtained from mosquitoes and rodents since 1980 and have been associated with
acute febrile illness in humans. However, no studies of RNV have been performed in the central area of the country.
We carried out molecular and serological detection of RNV in Córdoba, a province of the central part of the
country, in mosquitoes and humans, respectively. One mosquito pool tested positive for alphavirus RNA by reverse
transcriptase-nested polymerase chain reaction (RT-nested PCR). Subsequent sequencing determined that this alphavirus
grouped with RNV. Serological studies detected antibodies to RNV in one human serum sample, which was
obtained during the same period that RNV was detected using the aforementioned molecular methods. This is the
first report of RNV circulation in the central area of Argentina, indicating an expansion of its original distribution.
These results highlight the importance of strengthening surveillance procedures in endemic areas, as well as in new
regions where RNV may emerge.
Rio Negro virus - Venezuelan equine encephalitis - Argentina
Alternative site location: http://memorias.ioc.fiocruz.br