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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 107, No. 1, 2012, pp. 129-134
Bioline Code: oc12018
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 107, No. 1, 2012, pp. 129-134

 en Pfcrt check for this species in other resources haplotypes and the evolutionary history of chloroquine-resistant Plasmodium falciparum check for this species in other resources
Awasthi, Gauri; Satya, Godavarthi Bhogendra Krishna & Das, Aparup

Abstract

Mutations in the Pfcrt check for this species in other resources gene that change the resulting amino acids and form different haplotypes are common and correlate with the prevalence of chloroquine resistant (CQR) field isolates of the malaria parasite, Plasmodium falciparum check for this species in other resources . This correlation provides opportunities to infer the global evolutionary history of CQ resistance by analysing CQR Pfcrt haplotype data. We collated data on the Pfcrt haplotypes from different global studies and performed evolutionary genetic analysis to present comprehensive and comparative information on the global distribution of five major CQR-Pfcrt haplotypes and evolutionary inter-relationships among 38 different countries. Using the haplotype diversity data, inter-continental genetic differentiation was also ascertained.

Keywords
CQR-Pfcrt haplotypes - malaria - evolution

 
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