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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 107, No. 1, 2012, pp. 138-141
Bioline Code: oc12020
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 107, No. 1, 2012, pp. 138-141

 en Recognition of enteroinvasive Escherichia coli check for this species in other resources and Shigella flexneri check for this species in other resources by dendritic cells: distinct dendritic cell activation states
Moreno, Ana Carolina Ramos; Ferreira, Karen Spadari; Ferreira, Lucas Gonçalves; Rogério de Almeida, Sandro & Martinez, Marina Baquerizo

Abstract

The innate and adaptive immune responses of dendritic cells (DCs) to enteroinvasive Escherichia coli check for this species in other resources (EIEC) infection were compared with DC responses to Shigella flexneri check for this species in other resources infection. EIEC triggered DCs to produce interleukin (IL)-10, IL-12 and tumour necrosis factor (TNF)-α, whereas S. flexneri induced only the production of TNF-α. Unlike S. flexneri, EIEC strongly increased the expression of toll like receptor (TLR)-4 and TLR-5 in DCs and diminished the expression of co-stimulatory molecules that may cooperate to inhibit CD4+ T-lymphocyte proliferation. The inflammation elicited by EIEC seems to be related to innate immunity both because of the aforementioned results and because only EIEC were able to stimulate DC transmigration across polarised Caco-2 cell monolayers, a mechanism likely to be associated with the secretion of CC chemokine ligands (CCL)20 and TNF-α. Understanding intestinal DC biology is critical to unravelling the infection strategies of EIEC and may aid in the design of treatments for infectious diseases

Keywords
enteroinvasive Escherichia coli - Shigella flexneri - dendritic cells - innate immune response

 
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