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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060 EISSN: 1678-8060
Vol. 107, No. 2, 2012, pp. 205-210
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Bioline Code: oc12030
Full paper language: English
Document type: Research Article
Document available free of charge
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Memórias do Instituto Oswaldo Cruz, Vol. 107, No. 2, 2012, pp. 205-210
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Co-infections associated with human immunodeficiency virus type 1 in pregnant women from southern brazil: high rate of intraepithelial cervical lesions
Tornatore, Michele; Gonçalves, Carla Vitola; Bianchi, Mônica Steigleder; Germano, Fabiana Nunes; Garcés, Alzira Xavier; Soares, Marcelo Alves; Machado, Elizabeth Stankiewicz & de Martinez, Ana Maria Barral
Abstract
Human immunodeficiency virus type 1 (HIV-positive) pregnant women require specific prophylactic and therapeutic
approaches. The efficacy of established approaches is further challenged by co-infection with other sexually transmitted
diseases (STDs). The objective of this study was to determine the prevalence of co-infections in pregnant
women infected with different HIV-1 subtypes and to relate these findings, together with additional demographic
and clinical parameters, to maternal and infant outcomes. Blood samples from pregnant women were collected and
tested for syphilis, hepatitis B virus (HBV) and hepatitis C virus (HCV). Human papillomavirus (HPV) diagnosis
was evaluated by the presence of alterations in the cervical epithelium detected through a cytopathological exam.
Medical charts provided patient data for the mothers and children. Statistical analyses were conducted with STATA
9.0. We found a prevalence of 10.8% for HCV, 2.3% for chronic HBV, 3.1% for syphilis and 40.8% for HPV. Of those
co-infected with HPV, 52.9% presented high-grade intraepithelial lesions or in situ carcinoma. Prematurity, birth
weight, Apgar 1’ and 5’ and Capurro scores were similar between co-infected and non-co-infected women. The presence
of other STDs did not impact maternal and concept outcomes. More than half of the patients presenting cervical
cytology abnormalities suggestive of HPV had high-grade squamous intraepithelial lesions or cervical cancer,
evidencing an alarming rate of these lesions.
Keywords
pregnancy - HIV-1 - co-infections - STDs - cervical carcinoma
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