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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 107, No. 3, 2012, pp. 420-423
Bioline Code: oc12060
Full paper language: English
Document type: Study
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 107, No. 3, 2012, pp. 420-423

 en Changing the epidemiology of carbapenem-resistant Pseudomonas aeruginosa check for this species in other resources in a Brazilian teaching hospital: the replacement of São Paulo metallo-β-lactamase-producing isolates
Cavalcanti, Felipe Lira de Sá; Almeida, Anna Carolina Soares; Vilela, Marinalda Anselmo; de Morais, Marcia Maria Camargo & Junior, Marcos Antonio de Morais


In Brazil, carbapenem-resistant Pseudomonas aeruginosa check for this species in other resources isolates are closely related to the São Paulo metallo-β-lactamase (SPM) Brazilian clone. In this study, imipenem-resistant isolates were divided in two sets, 2002/2003 and 2008/2009, analysed by pulsed field gel electrophoresis and tested for the Ambler class B metallo-β-lactamase (MBL) genes blaSPM-1, blaIMP and blaVIM. The results show a prevalence of one clone related to the SPM Brazilian clone in 2002/2003. In 2008/2009, P. aeruginosa isolates were mostly MBL negative, genetically diverse and unrelated to those that had been detected earlier. These findings suggest that the resistance to carbapenems by these recent P. aeruginosa isolates was not due to the spread of MBL-positive SPM-related clones, as often observed in Brazilian hospitals.

carbapenemases - metallo-β-lactamase - Pseudomonas aeruginosa

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