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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 107, No. 3, 2012, pp. 433-436
Bioline Code: oc12063
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 107, No. 3, 2012, pp. 433-436

 en The activity of echinocandins, amphotericin B and voriconazole against fluconazole-susceptible and fluconazole-resistant Brazilian Candida glabrata isolates
Mario, Débora Alves Nunes; Denardi, Laura Bedin; Bandeira, Laíssa Arévalo; Antunes, Milene Silva; Santurio, Janio Morais; Severo, Luiz Carlos & Alves, Sydney Hartz


The extensive use of azole antifungal agents has promoted the resistance of Candida spp to these drugs. Candida glabrata check for this species in other resources is a problematic yeast because it presents a high degree of primary or secondary resistance to fluconazole. In Brazil, C. glabrata has been less studied than other species. In this paper, we compared the activity of three major classes of antifungal agents (azoles, echinocandins and polyenes) against fluconazole-susceptible (FS) and fluconazole-resistant (FR) C. glabrata strains. Cross-resistance between fluconazole and voriconazole was remarkable. Among the antifungal agents, the echinocandins were the most effective against FS and FR C. glabrata and micafungin showed the lowest minimal inhibitory concentrations.

Candida glabrata - echinocandins - antifungal drug resistance

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