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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 107, No. 6, 2012, pp. 816-819
Bioline Code: oc12127
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 107, No. 6, 2012, pp. 816-819

 en Distinct subcellular localization of tRNA-derived fragments in the infective metacyclic forms of Trypanosoma cruzi check for this species in other resources
Reifur, Larissa; Garcia-Silva, Maria Rosa; Poubel, Saloê Bispo; Alves, Lysangela Ronalte; Arauco, Paulo; Buiar, Diane Kelly; Goldenberg, Samuel; Cayota, Alfonso & Dallagiovanna, Bruno

Abstract

Small non-coding RNAs derived from transfer RNAs have been identified as a broadly conserved prokaryotic and eukaryotic response to stress. Their presence coincides with changes in developmental state associated with gene expression regulation. In the epimastigote form of Trypanosoma cruzi check for this species in other resources , tRNA fragments localize to posterior cytoplasmic granules. In the infective metacyclic form of the parasite, we found tRNA-derived fragments to be abundant and evenly distributed within the cytoplasm. The fragments were not associated with polysomes, suggesting that the tRNA-derived fragments may not be directly involved in translation control in metacyclics.

Keywords
Trypanosoma cruzi - tRNA-derived fragments - subcellular localisation

 
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