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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 107, No. 6, 2012, pp. 820-823
Bioline Code: oc12128
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 107, No. 6, 2012, pp. 820-823

 en The in vivo antimalarial activity of methylene blue combined with pyrimethamine, chloroquine and quinine
Garavito, Giovanny; Bertani, Stéphane; Quiliano, Miguel; Valentin, Alexis; Aldana, Ignacio & Deharo, Eric

Abstract

The effectiveness of methylene blue (MB) combined with pyrimethamine (PYR), chloroquine (CQ) or quinine (Q) was examined in a classical four-day suppressive test against a causative agent of rodent malaria, Plasmodium berghei check for this species in other resources . A marked potentiation was observed when MB was administered at a non-curative dose of 15 mg/kg/dayin combination with PYR (0.19 mg/kg/day) or Q (25 mg/kg/day). No synergy was found between MB (15 mg/Kg) and CQ (0.75 mg/Kg). Our results suggest that the combination of MB with PYR or Q may improve the efficacy of these currently used antimalarial drugs.

Keywords
antimalarials - methylene blue - drug combination

 
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