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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 108, No. 1, 2013, pp. 113-115
Bioline Code: oc13019
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 108, No. 1, 2013, pp. 113-115

 en Outbreak of carbapenem-resistant Klebsiella pneumoniae check for this species in other resources : two-year epidemiologic follow-up in a tertiary hospital
Pereira, Graziella Hanna; Garcia, Doroti O; Mostardeiro, Marcelo; Fanti, Karina SVN & Levin, Anna S

Abstract

This study describes a carbapenem-resistant Klebsiella pneumoniae check for this species in other resources (CRKP) outbreak that occurred from October 2008-December 2010. Polymerase chain reaction assays were performed to detect the blaKPC gene and molecular typing was performed using pulsed-field gel electrophoresis (PFGE). There were 33 CRKP infections; PFGE revealed five genotypes: genotype A in five (15%), B in 18 (55%), C in eight (24%) and two unique profiles. Genotype B was disseminated in all hospital units and belonged to the same clone identified in 11 different hospitals in the state of São Paulo. Sixteen (48%) patients died. Seven isolates (21%) were resistant to polymyxin B and 45% were resistant to tigecycline and amikacin.

Keywords
carbapenem-resistant K. pneumoniae - nosocomial outbreak - polymyxin resistance

 
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