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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 108, No. 4, 2013, pp. 508-511
Bioline Code: oc13086
Full paper language: English
Document type: Short Communication
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 108, No. 4, 2013, pp. 508-511

 en Comparison of the infectivity of Trypanosoma cruzi check for this species in other resources insect-derived metacyclic trypomastigotes after mucosal and cutaneous contaminative challenges
Eickhoff, Christopher Steven; Dunn, Brian Anthony; Sullivan, Nicole Lea & Hoft, Daniel Fredric


Trypanosoma cruzi check for this species in other resources infects humans when infected triatomine vector excreta contaminate breaks in skin or mucosal surfaces. T. cruzi insect‑derived metacyclic trypomastigotes (IMT) invade through gastric mucosa after oral challenges without any visible inflammatory changes, while cutaneous and conjunctival infections result in obvious local physical signs. In this study we compared the infectivity of T. cruzi IMT in mice after cutaneous and oral contaminative challenges simulating natural infections. The 50% infective dose (ID50) for oral challenge was 100 fold lower than the ID50 for cutaneous challenge, indicating that oral mucosal transmission is more efficient than cutaneous transmission.

Trypanosoma cruzi; mucosal immunity; Chagas disease; animal disease models; infection control

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