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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 108, No. 5, 2013, pp. 657-660
Bioline Code: oc13112
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 108, No. 5, 2013, pp. 657-660

 en Prevalence of occult hepatitis B virus infection in kidney transplant recipients
Franz, Cibele; Perez, Renata de Mello; Zalis, Mariano Gustavo; Zalona, Ana Carolina Jonard; de Castro e Abreu Rocha, Pedro Túlio Monteiro; Gonçalves, Renato Torres; Nabuco, Letícia Cancella & Villela-Nogueira, Cristiane Alves

Abstract

In this cross-sectional study, 207 hepatitis B surface antigen (HBsAg)-negative kidney transplant recipients were evaluated based on demographic and epidemiological data and on the levels of serological markers of hepatitis B virus (HBV) and hepatitis C virus infection and liver enzymes. Patients with HBV or human immunodeficiency virus infection were excluded. Sera were analysed for the presence of HBV-DNA. HBV-DNA was detected in two patients (1%), indicating occult hepatitis B (OHB) infection (the HBV-DNA loads were 3.1 and 3.5 IU/mL in these patients). The results of the liver function tests were normal and no serological markers indicative of HBV infection were detected. The prevalence of OHB infection was low among kidney transplant recipients, most likely due to the low HBsAg endemicity in the general population of the study area.

Keywords
occult hepatitis B infection; HBV-DNA; kidney transplantation

 
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