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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 108, No. 6, 2013, pp. 796-800
Bioline Code: oc13130
Full paper language: English
Document type: Short Communication
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 108, No. 6, 2013, pp. 796-800

 en Asymptomatic infection in individuals from the municipality of Barcelos (Brazilian Amazon) is not associated with the anti- Plasmodium falciparum check for this species in other resources glycosylphosphatidylinositol antibody response
Rodrigues Gomes, Larissa; Rivas Totino, Paulo Renato; Arroyo Sanchez, Maria Carmen; da Silva Kaingona Daniel, Elsa Paula; Santos de Macedo, Cristiana; Fortes, Filomeno; Coura, José Rodrigues; Di Santi, Silvia Maria; Loureiro Werneck, Guilherme; Suárez-Mutis, Martha Cecilia; de Fátima Ferreira-da-Cruz, Maria & Daniel-Ribeiro, Cláudio Tadeu

Abstract

Anti-glycosylphosphatidylinositol (GPI) antibodies (Abs) may reflect and mediate, at least partially, anti-disease immunity in malaria by neutralising the toxic effect of parasitic GPI. Thus, we assessed the anti-GPI Ab response in asymptomatic individuals living in an area of the Brazilian Amazon that has a high level of malaria transmission. For comparative purposes, we also investigated the Ab response to a crude extract prepared from Plasmodium falciparum check for this species in other resources , the merozoite surface protein (MSP)3 antigen of P. falciparum and the MSP 1 antigen of Plasmodium vivax check for this species in other resources (PvMSP1-19) in these individuals and in Angolan patients with acute malaria. Our data suggest that the Ab response against P. falciparum GPI is not associated with P. falciparum asymptomatic infection in individuals who have been chronically exposed to malaria in the Brazilian Amazon. However, this Ab response could be related to ongoing parasitaemia (as was previously shown) in the Angolan patients. In addition, our data show that PvMSP1-19 may be a good marker antigen to reflect previous exposure to Plasmodium in areas that have a high transmission rate of P. vivax.

Keywords
Plasmodium falciparum; Plasmodium vivax; glycosylphosphatidylinositol; asymptomatic infection; Brazilian Amazon; Angola

 
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