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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 108, No. 6, 2013, pp. 801-803
Bioline Code: oc13131
Full paper language: English
Document type: Short Communication
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 108, No. 6, 2013, pp. 801-803

 en Red blood cells derived from peripheral blood and bone marrow CD34+ human haematopoietic stem cells are permissive to Plasmodium check for this species in other resources parasites infection
Fernandez-Becerra, Carmen; Lelievre, Joel; Ferrer, Mireia; Anton, Nuria; Thomson, Richard; Peligero, Cristina; Jesus Almela, Maria; Lacerda, Marcus V.G.; Herreros, Esperanza & del Portillo, Hernando A.

Abstract

The production of fully functional human red cells in vitro from haematopoietic stem cells (hHSCs) has been successfully achieved. Recently, the use of hHSCs from cord blood represented a major improvement to develop the continuous culture system for Plasmodium vivax check for this species in other resources . Here, we demonstrated that CD34+ hHSCs from peripheral blood and bone marrow can be expanded and differentiated to reticulocytes using a novel stromal cell. Moreover, these reticulocytes and mature red blood cells express surface markers for entrance of malaria parasites contain adult haemoglobin and are also permissive to invasion by P. vivax and Plasmodium falciparum check for this species in other resources parasites.

Keywords
CD34+ human haematopoietic stem cells; NIH 3T3 cells; Plasmodium

 
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