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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 108, No. 6, 2013, pp. 808-811
Bioline Code: oc13133
Full paper language: English
Document type: Short Communication
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 108, No. 6, 2013, pp. 808-811

 en Phospholipase gene expression during Paracoccidioides brasiliensis check for this species in other resources morphological transition and infection
Soares, Deyze Alencar; Oliveira, Marilia Barros; Evangelista, Adriane Feijó; Venancio, Emerson José; Andrade, Rosângela Vieira; Soares Felipe, Maria Sueli & Petrofeza, Silvana

Abstract

Phospholipase is an important virulence factor for pathogenic fungi. In this study, we demonstrate the following: (i) the Paracoccidioides brasiliensis check for this species in other resources pld gene is preferentially expressed in mycelium cells, (ii) the plb1 gene is mostly up-regulated by infection after 6 h of co-infection of MH-S cells or during BALB/c mice lung infection, (iii) during lung infection, plb1, plc and pld gene expression are significantly increased 6-48 h post-infection compared to 56 days after infection, strongly suggesting that phospholipases play a role in the early events of infection, but not during the chronic stages of pulmonary infection by P. brasiliensis.

Keywords
host-pathogen interaction; Paracoccidioides brasiliensis; pathogenicity; phospholipases

 
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