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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 108, No. 7, 2013, pp. 850-853
Bioline Code: oc13143
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 108, No. 7, 2013, pp. 850-853

 en Imatinib activity on Schistosoma mansoni check for this species in other resources
Katz, Naftale; Couto, Flαvia Fernanda Bubulo & Araújo, Neusa

Abstract

Imatinib, a drug used for treatment of human chronic myeloid leukaemia, due to its activity against protein kinases, has been also evaluated in vitro against Schistosoma mansoni check for this species in other resources showing high schistosomicidal activity. In the present experiments imatinib activity in vitro was confirmed at the doses of 25 μM, 50 μM and 100 μM. The first drug activity observed with the lower dose was interruption of egg-laying and with the higher dosages was the death of the worms. In mice infected with S. mansoni no activity was found even with 1,000 mg/kg/day, 500 mg/kg/day, single oral dose or when administered for three consecutive days. This is another example of the difference of results related to in vitro and in vivo trials using S. mansoni worms.

Keywords
schistosomiasis; chemotherapy; imatinib

 
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