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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 109, No. 1, 2014, pp. 51-60
Bioline Code: oc14007
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 109, No. 1, 2014, pp. 51-60

 en Myenteric plexus is differentially affected by infection with distinct Trypanosoma cruzi check for this species in other resources strains in Beagle dogs
Nogueira-Paiva, Nívia Carolina; da Silva Fonseca, Kátia; de Abreu Vieira, Paula Melo; Figueiredo Diniz, Lívia; Santana Caldas, Ivo; Lima de Moura, Sandra Aparecida; Maria Veloso, Vanja; da Matta Guedes, Paulo Marcos; Luiz Tafuri, Washington; Terezinha Bahia, Maria & Carneiro, Cláudia Martins

Abstract

Chagasic megaoesophagus and megacolon are characterised by motor abnormalities related to enteric nervous system lesions and their development seems to be related to geographic distribution of distinct Trypanosoma cruzi check for this species in other resources subpopulations. Beagle dogs were infected with Y or Berenice-78 (Be-78) T. cruzi strains and necropsied during the acute or chronic phase of experimental disease for post mortem histopathological evaluation of the oesophagus and colon. Both strains infected the oesophagus and colon and caused an inflammatory response during the acute phase. In the chronic phase, inflammatory process was observed exclusively in the Be-78 infected animals, possibly due to a parasitism persistent only in this group. Myenteric denervation occurred during the acute phase of infection for both strains, but persisted chronically only in Be-78 infected animals. Glial cell involvement occurred earlier in animals infected with the Y strain, while animals infected with the Be-78 strain showed reduced glial fibrillary acidic protein immunoreactive area of enteric glial cells in the chronic phase. These results suggest that although both strains cause lesions in the digestive tract, the Y strain is associated with early control of the lesion, while the Be-78 strain results in progressive gut lesions in this model.

Keywords
dog; Trypanosoma cruzi; myenteric plexus

 
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