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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 109, No. 5, 2014, pp. 522-524
Bioline Code: oc14084
Full paper language: English
Document type: View Point
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 109, No. 5, 2014, pp. 522-524

 en Plasmodium vivax malaria elimination: should innovative ideas from the past be revisited?
Val, Fernando Fonseca; Sampaio, Vanderson Souza; Cassera, Maria Belén; Andrade, Raquel Tapajós; Tauil, Pedro Luiz; Monteiro, Wuelton Marcelo & Lacerda, Marcus Vinícius Guimarães

Abstract

In the 1950s, the strategy of adding chloroquine to food salt as a prophylaxis against malaria was considered to be a successful tool. However, with the development of Plasmodium resistance in the Brazilian Amazon, this control strategy was abandoned. More than 50 years later, asexual stage resistance can be avoided by screening for antimalarial drugs that have a selective action against gametocytes, thus old prophylactic measures can be revisited. The efficacy of the old methods should be tested as complementary tools for the elimination of malaria.

Keywords
malaria; Plasmodium; elimination; control; antimalarials; salt

 
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