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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 109, No. 5, 2014, pp. 644-661
Bioline Code: oc14098
Full paper language: English
Document type: Review Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 109, No. 5, 2014, pp. 644-661

 en The Plasmodium bottleneck: malaria parasite losses in the mosquito vector
Smith, Ryan C.; Vega-Rodríguez, Joel & Jacobs-Lorena, Marcelo

Abstract

Nearly one million people are killed every year by the malaria parasite Plasmodium. Although the disease-causing forms of the parasite exist only in the human blood, mosquitoes of the genus Anopheles check for this species in other resources are the obligate vector for transmission. Here, we review the parasite life cycle in the vector and highlight the human and mosquito contributions that limit malaria parasite development in the mosquito host. We address parasite killing in its mosquito host and bottlenecks in parasite numbers that might guide intervention strategies to prevent transmission.

Keywords
malaria; mosquito; Plasmodium; innate immunity

 
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