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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 109, No. 7, 2014, pp. 918-922
Bioline Code: oc14135
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 109, No. 7, 2014, pp. 918-922

 en DEFB1 polymorphisms are involved in susceptibility to human papillomavirus infection in Brazilian gynaecological patients
Segat, Ludovica; Zupin, Luisa; Moura, Ronald Rodrigues; Coelho, Antonio Victor Campos; Chagas, Bárbara Simas; de Freitas, Antonio Carlos & Crovella, Sergio

Abstract

The human beta defensin 1 (hBD-1) antimicrobial peptide is a member of the innate immune system known to act in the first line of defence against microorganisms, including viruses such as human papillomavirus (HPV). In this study, five functional polymorphisms (namely g-52G>A, g-44C>G and g-20G>A in the 5’UTR and c.*5G>A and c.*87A>G in the 3’UTR) in the DEFB1 gene encoding for hBD-1 were analysed to investigate the possible involvement of these genetic variants in susceptibility to HPV infection and in the development of HPV-associated lesions in a population of Brazilian women. The DEFB1 g-52G>A and c.*5G>A single-nucleotide polymorphisms (SNPs) and the GCAAA haplotype showed associations with HPV-negative status; in particular, the c.*5G>A SNP was significantly associated after multiple test corrections. These findings suggest a possible role for the constitutively expressed beta defensin-1 peptide as a natural defence against HPV in the genital tract mucosa.

Keywords
DEFB1; antimicrobial peptides; human papillomavirus; genetic polymorphisms; cervical lesion

 
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