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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 109, No. 7, 2014, pp. 940-943
Bioline Code: oc14138
Full paper language: English
Document type: Short Communication
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 109, No. 7, 2014, pp. 940-943

 en Interferon-γ inhibits group B Streptococcus check for this species in other resources survival within human endothelial cells
Lione, Viviane de Oliveira Freitas; dos Santos, Michelle Hanthequeste Bittencourt; de Oliveira, Jessica Silva Santos; Mattos-Guaraldi, Ana Luiza & Nagao, Prescilla Emy


Endothelial dysfunction is a major component of the pathophysiology of septicaemic group B Streptococcus check for this species in other resources (GBS) infections. Although cytokines have been shown to activate human umbilical vein endothelial cells (HUVECs), the capacity of interferon (IFN)-γ to enhance the microbicidal activity of HUVECs against GBS has not been studied. We report that the viability of intracellular bacteria was reduced in HUVECs activated by IFN-γ. Enhanced fusion of lysosomes with bacteria-containing vacuoles was observed by acid phosphatase and the colocalisation of Rab-5, Rab-7 and lysosomal-associated membrane protein-1 with GBS in IFN-γ-activated HUVECs. IFN-γ resulted in an enhancement of the phagosome maturation process in HUVECs, improving the capacity to control the intracellular survival of GBS.

group B Streptococcus; IFN-γ; survival

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