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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 109, No. 7, 2014, pp. 972-974
Bioline Code: oc14146
Full paper language: English
Document type: Discussion
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 109, No. 7, 2014, pp. 972-974

 en Complete genome sequence of a clinical Bordetella pertussis check for this species in other resources isolate from Brazil
Andrade, Bruno Gabriel N.; Marin, Michel F. Abanto; Cambuy, Diego Duque; Fonseca, Erica Lourenço; Souza, Nadjla Ferreira & Vicente, Ana Carolina P.

Abstract

There has been a resurgence in the number of pertussis cases in Brazil and around the world. Here, the genome of a clinical Bordetella pertussis check for this species in other resources strain (Bz181) that was recently isolated in Brazil is reported. Analysis of the virulence-associated genes defining the pre- and post-vaccination lineages revealed the presence of the prn2-ptxS1A-fim3B-ptxP3 allelic profile in Bz181, which is characteristic of the current pandemic lineage. A putative metallo-β-lactamase gene presenting all of the conserved zinc-binding motifs that characterise the catalytic site was identified, in addition to a multidrug efflux pump of the RND family that could confer resistance to erythromycin, which is the antibiotic of choice for treating pertussis disease.

Keywords
ptxP3; pandemic lineage; virulence factors; antigenic variant

 
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