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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 109, No. 8, 2014, pp. 1005-1013
Bioline Code: oc14152
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 109, No. 8, 2014, pp. 1005-1013

 en The TcI and TcII Trypanosoma cruzi check for this species in other resources experimental infections induce distinct immune responses and cardiac fibrosis in dogs
Duz, Ana Luiza Cassin; de Abreu Vieira, Paula Melo; Roatt, Bruno Mendes; Anguiar-Soares, Rodrigo Dian Oliveira; de Oliveira Cardoso, Jamille Mirelle; de Oliveira, Flávia Carvalho Bitencourt; Reis, Levi Eduardo Soares; Tafuri, Washington Luiz; Veloso, Vanja Maria; Reis, Alexandre Barbosa & Carneiro, Cláudia Martins

Abstract

Trypanosoma cruzi check for this species in other resources infection may be caused by different strains with distinct discrete typing units (DTUs) that can result in variable clinical forms of chronic Chagas disease. The present study evaluates the immune response and cardiac lesions in dogs experimentally infected with different T. cruzi strains with distinct DTUs, namely, the Colombian (Col) and Y strains of TcI and TcII DTU, respectively. During infection with the Col strain, increased levels of alanine aminotransferase, erythrocytes, haematocrit and haemoglobin were observed. In addition, CD8+ T-lymphocytes isolated from the peripheral blood produced higher levels of interleukin (IL)-4. The latter suggests that during the acute phase, infection with the Col strain may remain unnoticed by circulating mononuclear cells. In the chronic phase, a significant increase in the number of inflammatory cells was detected in the right atrium. Conversely, infection with the Y strain led to leucopoenia, thrombopoenia, inversion of the ratio of CD4+/CD8+ T-lymphocytes and alterations in monocyte number. The Y strain stimulated the production of interferon-γ by CD4+ and CD8+ T-lymphocytes and IL-4 by CD8+ T-cells. In the chronic phase, significant heart inflammation and fibrosis were observed, demonstrating that strains of different DTUs interact differently with the host.

Keywords
Trypanosoma cruzi; strain; dog; immune response; cardiac inflammation

 
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