Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
Vol. 110, No. 2, 2015, pp. 263-266
Bioline Code: oc15034
Full paper language: English
Document type: Research Article
Document available free of charge
Memórias do Instituto Oswaldo Cruz, Vol. 110, No. 2, 2015, pp. 263-266
© Copyright - 2015 - Memórias do Instituto Oswaldo Cruz
T-helper 17-related cytokines and IgE antibodies during hepatitis A virus infection in children|
Trujillo-Ochoa, Jorge L.; Corral-Jara, Karla F.; Escobedo-Meléndez, Griselda; Realpe, Mauricio; Panduro, Arturo; Roman, Sonia & Fierro, Nora A.
We determined the serum IgE levels and T-helper (Th)17-related cytokines during distinct hepatitis A virus (HAV)-induced clinical courses in children. A significantly higher concentration of macrophage inflammatory protein 3α, interleukin (IL)-17E and IL-17F in HAV-infected children with intermediate liver injury compared with those with minor liver damage was found. A reduction in the IgE levels in those patients who showed the highest levels of IL-17F in the group of intermediate liver injury was found. The data suggested that the Th17-related profile is associated with the severity of HAV infection and might play a role on the modulation achieved by HAV during allergies.
hepatitis A virus; IgE; Th17; cytokines
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