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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 110, No. 3, 2015, pp. 369-376
Bioline Code: oc15048
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 110, No. 3, 2015, pp. 369-376

 en Congenital transmission of Trypanosoma cruzi in central Brazil. A study of 1,211 individuals born to infected mothers
Luquetti, Alejandro O.; do Nascimento Tavares, Suelene Brito; da Rocha Siriano, Liliane; de Oliveira, Rozângela Amaral; Campos, Dayse Elizabeth; de Morais, Cicilio Alves & de Oliveira, Enio Chaves

Abstract

Transmission of Trypanosoma cruzi during pregnancy is estimated to occur in less than 20% of infected mothers; however, the etiopathogenesis is not completely understood. The Centre for Studies on Chagas Disease provides confirmation of T. cruzi infection for individuals living in central Brazil. In this retrospective hospital-based study, all requests for diagnosis of T. cruzi infection in individuals less than 21 years old from 1994-2014 were searched. We end with 1,211 individuals and their respective infected mothers. Congenital transmission of infection was confirmed in 24 individuals (2%) in central Brazil, an area where the main T. cruzi lineage circulating in humans is TcII. This low prevalence of congenital Chagas disease is discussed in relation to recent findings in the south region of Brazil, where TcV is the main lineage and congenital transmission has a higher prevalence (approximately 5%), similar to frequencies reported in Argentina, Paraguay and Bolivia. This is the first report to show geographical differences in the rates of congenital transmission of T. cruzi and the relationship between the prevalence of congenital transmission and the type of Tc prevalent in each region.

Keywords
Chagas disease; Trypanosoma cruzi; congenital transmission; geographical differences; familial studies

 
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