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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 110, No. 4, 2015, pp. 566-568
Bioline Code: oc15072
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 110, No. 4, 2015, pp. 566-568

 en In vitro activity of 1,3-bisaryloxypropanamines against Trypanosoma cruzi-infected L929 cultures
Lavorato, Stefânia Neiva; Júnior, Policarpo Ademar Sales; Murta, Silvane Maria Fonseca; Romanha, Alvaro José & Alves, Ricardo José

Abstract

We describe herein the antitrypanosomal activity of 20 novel 1,3-bis(aryloxy)propan-2-amine derivatives. Compounds 2, 4, 6, 12, 15, 16 and 19 were significantly active against amastigote and trypomastigote forms, with half maximal inhibitory concentration values in the range of 6-18 ìM. In the cytotoxicity tests against L929 cells, only compound 4 presented selectivity index value above 10, indicating low toxicity.

Keywords
Trypanosoma cruzi; antitrypanosomal agents; Chagas disease; 1,3-bisaryloxypropanamines

 
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