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In vitro activity of 1,3-bisaryloxypropanamines against Trypanosoma cruzi-infected L929 cultures
Lavorato, Stefânia Neiva; Júnior, Policarpo Ademar Sales; Murta, Silvane Maria Fonseca; Romanha, Alvaro José & Alves, Ricardo José
Abstract
We describe herein the antitrypanosomal activity of 20 novel 1,3-bis(aryloxy)propan-2-amine derivatives. Compounds
2, 4, 6, 12, 15, 16 and 19 were significantly active against amastigote and trypomastigote forms, with half
maximal inhibitory concentration values in the range of 6-18 ìM. In the cytotoxicity tests against L929 cells, only
compound 4 presented selectivity index value above 10, indicating low toxicity.
Keywords
Trypanosoma cruzi; antitrypanosomal agents; Chagas disease; 1,3-bisaryloxypropanamines
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