The emergence of multidrug-resistant Enterobacteriaceae strains producing carbapenemases, such as NDM-1, has
become a major public health issue due to a high dissemination capacity and limited treatment options. Here we describe
the draft genome of three NDM-1-producing isolates:
Providencia rettgeri
(CCBH11880),
Enterobacter hormaechei
subsp.
oharae (CCBH10892) and
Klebsiella pneumoniae
(CCBH13327), isolated in Brazil. Besides
blaNDM-1, resistance genes
to aminoglycosides [
aadA1, aadA2, aac(6’)-Ib-cr] and quinolones (
qnrA1, qnrB4) were observed which contributed to
the multidrug resistance profile. The element ISAba125 was found associated to the
blaNDM-1 gene in all strains.
