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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 110, No. 4, 2015, pp. 580-582
Bioline Code: oc15076
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 110, No. 4, 2015, pp. 580-582

 en Draft genome sequences of three NDM-1-producing Enterobacteriaceae species isolated from Brazil
Pereira, Polyana Silva; Albano, Rodolpho Mattos; Asensi, Marise Dutra & Carvalho-Assef, Ana Paula D’Alincourt

Abstract

The emergence of multidrug-resistant Enterobacteriaceae strains producing carbapenemases, such as NDM-1, has become a major public health issue due to a high dissemination capacity and limited treatment options. Here we describe the draft genome of three NDM-1-producing isolates: Providencia rettgeri check for this species in other resources (CCBH11880), Enterobacter hormaechei check for this species in other resources subsp. oharae (CCBH10892) and Klebsiella pneumoniae check for this species in other resources (CCBH13327), isolated in Brazil. Besides blaNDM-1, resistance genes to aminoglycosides [aadA1, aadA2, aac(6’)-Ib-cr] and quinolones (qnrA1, qnrB4) were observed which contributed to the multidrug resistance profile. The element ISAba125 was found associated to the blaNDM-1 gene in all strains.

Keywords
NDM-1; Brazil; Enterobacteriaceae

 
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