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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 110, No. 5, 2015, pp. 629-635
Bioline Code: oc15085
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 110, No. 5, 2015, pp. 629-635

 en Biocontrol evaluation of extracts and a major component, clusianone, from Clusia fluminensis check for this species in other resources Planch. & Triana against Aedes aegypti check for this species in other resources
Anholeti, Maria C.; Duprat, Rodrigo C.; Figueiredo, Maria R.; Kaplan, Maria A. C.; Santos, Marcelo Guerra; Gonzalez, Marcelo S.; Ratcliffe, Norman A.; Feder, Denise; Paiva, Selma R. & Mello, Cicero B.

Abstract

Studies evaluated the effects of hexanic extracts from the fruits and flowers of Clusia fluminensis check for this species in other resources and the main component of the flower extract, a purified benzophenone (clusianone), against Aedes aegypti check for this species in other resources . The treatment of larvae with the crude fruit or flower extracts from C. fluminensis did not affect the survival of Ae. aegypti (50 mg/L), however, the flower extracts significantly delayed development of Ae. aegypti. In contrast, the clusianone (50 mg/L) isolate from the flower extract, representing 54.85% of this sample composition, showed a highly significant inhibition of survival, killing 93.3% of the larvae and completely blocking development of Ae. aegypti. The results showed, for the first time, high activity of clusianone against Ae. aegypti that both killed and inhibited mosquito development. Therefore, clusianone has potential for development as a biopesticide for controlling insect vectors of tropical diseases. Future work will elucidate the mode of action of clusianone isolated from C. fluminensis.

Keywords
clusianone; larvicidal; Clusia fluminensis; Aedes aegypti

 
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