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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060 EISSN: 1678-8060
Vol. 110, No. 6, 2015, pp. 804-808
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Bioline Code: oc15110
Full paper language: English
Document type: Short Communication
Document available free of charge
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Memórias do Instituto Oswaldo Cruz, Vol. 110, No. 6, 2015, pp. 804-808
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Evaluating anti-Orthopoxvirus antibodies in individuals from Brazilian rural areas prior to the bovine vaccinia era
Figueiredo, Poliana de Oliveira; da Silva-Fernandes, André Tavares; Mota, Bruno Eduardo Fernandes; Costa, Galileu Barbosa; Borges, Iara Apolinário; Ferreira, Paulo César Peregrino; Abrahão, Jônatas Santos; Braga, Erika Martins; Kroon, Erna Geessien & Trindade, Giliane de Souza
Abstract
Vaccinia virus naturally circulates in Brazil and is the causative agent of a zoonotic disease known as bovine vaccinia
(BV). We retrospectively evaluated two populations from the Amazon and Southeast Regions. BV outbreaks had
not been reported in these regions before sample collection. Neutralising antibodies were found in 13 individuals (n =
132) with titres ranging from 100 ≥ 6,400 neutralising units/mL. Univariate analysis identified age and vaccination as
statistically significant risk factors in individuals from the Southeast Region. The absence of detectable antibodies in
vaccinated individuals raises questions about the protection of smallpox vaccine years after vaccination and reinforces
the need for surveillance of Orthopoxvirus in Brazilian populations without evidence of previous outbreaks.
Keywords
Orthopoxvirus; smallpox vaccine; bovine vaccinia; retrospective serosurvey
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