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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 110, No. 6, 2015, pp. 814-816
Bioline Code: oc15112
Full paper language: English
Document type: Short Communication
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 110, No. 6, 2015, pp. 814-816

 en Whole-genome sequencing of a Plasmodium vivax isolate from the China-Myanmar border area
Shen, Hai-Mo; Chen, Shen-Bo; Wang, Yue & Chen, Jun-Hu

Abstract

Currently, there is a trend of an increasing number of Plasmodium vivax malaria cases in China that are imported across its Southeast Asia border, especially in the China-Myanmar border area (CMB). To date, little is known about the genetic diversity of P. vivax in this region. In this paper, we report the first genome sequencing of a P. vivax isolate (CMB-1) from a vivax malaria patient in CMB. The sequencing data were aligned onto 96.43% of the P. vivax Salvador I reference strain (Sal I) genome with 7.84-fold coverage as well as onto 98.32% of 14 Sal I chromosomes. Using the de novo assembly approach, we generated 8,541 scaffolds and assembled a total of 27.1 Mb of sequence into CMB-1 scaffolds. Furthermore, we identified all 295 known vir genes, which is the largest subtelomeric multigene family in malaria parasites. These results provide an important foundation for further research on P. vivax population genetics.

Keywords
Plasmodium vivax; genome; vir

 
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