|
Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060 EISSN: 1678-8060
Vol. 110, No. 6, 2015, pp. 814-816
|
Bioline Code: oc15112
Full paper language: English
Document type: Short Communication
Document available free of charge
|
|
Memórias do Instituto Oswaldo Cruz, Vol. 110, No. 6, 2015, pp. 814-816
en |
Whole-genome sequencing of a Plasmodium vivax isolate from the China-Myanmar border area
Shen, Hai-Mo; Chen, Shen-Bo; Wang, Yue & Chen, Jun-Hu
Abstract
Currently, there is a trend of an increasing number of Plasmodium vivax malaria cases in China that are imported
across its Southeast Asia border, especially in the China-Myanmar border area (CMB). To date, little is known about
the genetic diversity of P. vivax in this region. In this paper, we report the first genome sequencing of a P. vivax isolate
(CMB-1) from a vivax malaria patient in CMB. The sequencing data were aligned onto 96.43% of the P. vivax Salvador
I reference strain (Sal I) genome with 7.84-fold coverage as well as onto 98.32% of 14 Sal I chromosomes. Using the
de novo assembly approach, we generated 8,541 scaffolds and assembled a total of 27.1 Mb of sequence into CMB-1
scaffolds. Furthermore, we identified all 295 known vir genes, which is the largest subtelomeric multigene family in
malaria parasites. These results provide an important foundation for further research on P. vivax population genetics.
Keywords
Plasmodium vivax; genome; vir
|
|
© Copyright 2015 - Memórias do Instituto Oswaldo Cruz Alternative site location: http://memorias.ioc.fiocruz.br
|
|