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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060 EISSN: 1678-8060
Vol. 110, No. 7, 2015, pp. 914-920
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Bioline Code: oc15125
Full paper language: English
Document type: Research Article
Document available free of charge
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Memórias do Instituto Oswaldo Cruz, Vol. 110, No. 7, 2015, pp. 914-920
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Multibacillary leprosy patients with high and persistent serum antibodies to leprosy IDRI diagnostic-1/LID-1: higher susceptibility to develop type 2 reactions
de Freitas Mizoguti, Danielle; Mayra Hungria, Emerith; Araújo Freitas, Aline; Morillas Oliveira, Regiane; Paula Vaz Cardoso, Ludimila; Barcelos Costa, Mauricio; Lúcia Maroclo Sousa, Ana; Duthie, Malcolm S. & Martins Araújo Stefani, Mariane
Abstract
Leprosy inflammatory episodes [type 1 (T1R) and type 2 (T2R) reactions] represent the major cause of irreversible
nerve damage. Leprosy serology is known to be influenced by the patient’s bacterial index (BI) with higher positivity
in multibacillary patients (MB) and specific multidrug therapy (MDT) reduces antibody production. This study
evaluated by ELISA antibody responses to leprosy Infectious Disease Research Institute diagnostic-1 (LID-1) fusion
protein and phenolic glycolipid I (PGL-I) in 100 paired serum samples of 50 MB patients collected in the presence/
absence of reactions and in nonreactional patients before/after MDT. Patients who presented T2R had a median BI
of 3+, while MB patients with T1R and nonreactional patients had median BI of 2.5+ (p > 0.05). Anti-LID-1 and anti-
PGL-I antibodies declined in patients diagnosed during T1R (p < 0.05). Anti-LID-1 levels waned in MB with T2R
at diagnosis and nonreactional MB patients (p < 0.05). Higher anti-LID-1 levels were seen in patients with T2R at
diagnosis (vs. patients with T1R at diagnosis, p = 0.008; vs. nonreactional patients, p = 0.020) and in patients with
T2R during MDT (vs. nonreactional MB, p = 0.020). In MB patients, high and persistent anti-LID-1 antibody levels
might be a useful tool for clinicians to predict which patients are more susceptible to develop leprosy T2R.
Keywords
antibody; diagnosis; LID-1; leprosy reactions; serology; PGL-I
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