Vitamin D status in a Brazilian cohort of adolescents and young adults with perinatally acquired human immunodeficiency virus infection|
Schtscherbyna, Annie; Gouveia, Carla; Pinheiro, Maria Fernanda Miguens Castelar; Luiz, Ronir Raggio; Farias, Maria Lucia Fleiuss & Machado, Elizabeth Stankiewicz
The purpose was to determine the prevalence and related factors of vitamin D (VitD) insufficiency in adolescents
and young adults with perinatally acquired human immunodeficiency virus. A cohort of 65 patients (17.6 ± 2 years)
at the Federal University of Rio de Janeiro, Brazil, were examined for pubertal development, nutrition, serum parathormone
and serum 25-hydroxyvitamin D [s25(OH)D]. s25(OH)D levels < 30 ng/mL (< 75 nmol/L) were defined as
VitD insufficiency. CD4+ T-cell counts and viral load, history of worst clinical status, immunologic status as nadir,
current immunologic status, and antiretroviral (ART) regimen were also evaluated as risk factors for VitD insufficiency.
Mean s25(OH)D was 37.7 ± 13.9 ng/mL and 29.2% had VitD insufficiency. There was no difference between
VitD status and gender, age, nutritional status, clinical and immunological classification, and type of ART. Only
VitD consumption showed tendency of association with s25(OH)D (p = 0.064). Individuals analysed in summer/autumn
season had a higher s25(OH)D compared to the ones analysed in winter/spring (42.6 ± 14.9 vs. 34.0 ± 11.9, p =
0.011). Although, the frequency of VitD insufficiency did not differ statistically between the groups (summer/autumn
17.9% vs. winter/spring 37.8%, p = 0.102), we suggest to monitor s25(OH)D in seropositive adolescents and young
adults, especially during winter/spring months, even in sunny regions.
adolescent; perinatally acquired HIV; vitamin D; nutrition; Latin America