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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 111, No. 2, 2016, pp. 141-143
Bioline Code: oc16019
Full paper language: English
Document type: Report
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 111, No. 2, 2016, pp. 141-143

 en Complete genome of a dengue virus serotype 4 strain from Amazonas, Brazil
Nascimento, Valdinete Alves do; Souza, Victor Costa de & Naveca, Felipe Gomes

Abstract

Dengue virus (DENV) infections represent a significant concern for public health worldwide, being considered as the most prevalent arthropod-borne virus regarding the number of reported cases. In this study, we report the complete genome sequencing of a DENV serotype 4 isolate, genotype II, obtained in the city of Manaus, directly from the serum sample, applying Ion Torrent sequencing technology. The use of a massive sequencing technology allowed the detection of two variable sites, one in the coding region for the viral envelope protein and the other in the nonstructural 1 coding region within viral populations.

Keywords
Brazilian Amazon; dengue virus; DENV-4; viral genome; next-generation sequencing

 
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