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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060 EISSN: 1678-8060
Vol. 111, No. 4, 2016, pp. 275-276
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Bioline Code: oc16038
Full paper language: English
Document type: Short Communication
Document available free of charge
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Memórias do Instituto Oswaldo Cruz, Vol. 111, No. 4, 2016, pp. 275-276
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Correlation between TH1 response standard cytokines as biomarkers in patients with the delta virus in the western Brazilian Amazon
Nicolete, Larissa Deadame de Figueiredo; Borzacov, Lourdes Maria Pinheiro; Vieira, Deusilene Souza; Nicolete, Roberto & Salcedo, Juan Miguel Villalobos
Abstract
Hepatitis D virus (HDV) is endemic in the Amazon Region and its pathophysiology is the most severe among viral
hepatitis. Treatment is performed with pegylated interferon and the immune response appears to be important for
infection control. HDV patients were studied: untreated and polymerase chain reaction (PCR) positive (n = 9), anti-
HDV positive and PCR negative (n = 8), and responders to treatment (n = 12). The cytokines, interleukin (IL)-2 (p =
0.0008) and IL-12 (p = 0.02) were differentially expressed among the groups and were also correlated (p = 0.0143).
Future studies will be conducted with patients at different stages of treatment, associating the viral load with serum
cytokines produced, thereby attempting to establish a prognostic indicator of the infection.
Keywords
HDV; patients treated; TH1 cytokines
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