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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 111, No. 5, 2016, pp. 311-321
Bioline Code: oc16045
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 111, No. 5, 2016, pp. 311-321

 en Spatial and temporal country-wide survey of temephos resistance in Brazilian populations of Aedes aegypti check for this species in other resources
Chediak, Mateus; Pimenta Jr, Fabiano G.; Coelho, Giovanini E.; Braga, Ima A.; Lima, José Bento P.; Cavalcante, Karina Ribeiro L.J.; Sousa, Lindemberg C. de; Melo-Santos, Maria Alice V. de; Macoris, Maria de Lourdes da G.; Araújo, Ana Paula de; Ayres, Constância Flávia J.; Andrighetti, Maria Teresa M.; Gomes, Ricristhi Gonçalves de A.; Campos, Kauara B. & Guedes, Raul Narciso C.

Abstract

The organophosphate temephos has been the main insecticide used against larvae of the dengue and yellow fever mosquito ( Aedes aegypti check for this species in other resources ) in Brazil since the mid-1980s. Reports of resistance date back to 1995; however, no systematic reports of widespread temephos resistance have occurred to date. As resistance investigation is paramount for strategic decision-making by health officials, our objective here was to investigate the spatial and temporal spread of temephos resistance in Ae. aegypti in Brazil for the last 12 years using discriminating temephos concentrations and the bioassay protocols of the World Health Organization. The mortality results obtained were subjected to spatial analysis for distance interpolation using semi-variance models to generate maps that depict the spread of temephos resistance in Brazil since 1999. The problem has been expanding. Since 2002-2003, approximately half the country has exhibited mosquito populations resistant to temephos. The frequency of temephos resistance and, likely, control failures, which start when the insecticide mortality level drops below 80%, has increased even further since 2004. Few parts of Brazil are able to achieve the target 80% efficacy threshold by 2010/2011, resulting in a significant risk of control failure by temephos in most of the country. The widespread resistance to temephos in Brazilian Ae. aegypti populations greatly compromise effective mosquito control efforts using this insecticide and indicates the urgent need to identify alternative insecticides aided by the preventive elimination of potential mosquito breeding sites.

Keywords
insecticide resistance survey; dengue; distance interpolation; distribution maps; mosquito larvae

 
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