Primary dengue haemorrhagic fever in patients from northeast of Brazil is associated with high levels of interferon-b during acute phase|
Santos Oliveira, Renato Antônio dos; Carneiro da Silva, Mayara Marques; Calzavara-Silva, Carlos Eduardo; Silva, Ana Maria; Cordeiro, Marli Tenório; Freire de Moura, Patrícia Muniz Mendes; Baptista Filho, Paulo Neves; Marques Júnior, Ernesto Torres de Azevedo & Gonzales Gil, Laura Helena Vega
Dengue is an acute febrile disease caused by the mosquito-borne dengue virus (DENV) that according to clinical
manifestations can be classified as asymptomatic, mild or severe dengue. Severe dengue cases have been associated
with an unbalanced immune response characterised by an over secretion of inflammatory cytokines. In the present
study we measured type I interferon (IFN-I) transcript and circulating levels in primary and secondary DENV infected
patients. We observed that dengue fever (DF) and dengue haemorrhagic fever (DHF) patients express IFN-I
differently. While DF and DHF patients express interferon-a similarly (52,71 ± 7,40 and 49,05 ± 7,70, respectively),
high levels of circulating IFN-b were associated with primary DHF patients. On the other hand, secondary DHF
patients were not able to secrete large amounts of IFN-b which in turn may have influenced the high-level of viraemia.
Our results suggest that, in patients from our cohort, infection by DENV serotype 3 elicits an innate response
characterised by higher levels of IFN-b in the DHF patients with primary infection, which could contribute to control
infection evidenced by the low-level of viraemia in these patients. The present findings may contribute to shed
light in the role of innate immune response in dengue pathogenesis.
dengue fever; dengue haemorrhagic fever; type I interferon; innate immunity