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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 111, No. 6, 2016, pp. 407-410
Bioline Code: oc16060
Full paper language: English
Document type: Short Communication
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 111, No. 6, 2016, pp. 407-410

 en Candida duobushaemulonii: an emerging rare pathogenic yeast isolated from recurrent vulvovaginal candidiasis in Brazil
Boatto, Humberto Fabio; Barbosa Cavalcanti, Sarah Desirée; Del Negro, Gilda MB; BC Girão, Manoel João; Francisco, Elaine Cristina; Ishida, Kelly & Gompertz, Olga Fischman


The aim of this study was to identify Candida check for this species in other resources species isolated from women diagnosed with recurrent vulvovaginal candidiasis (RVVC) and their partners; and to evaluate the fluconazole (FLZ) susceptibility of the isolates. In a period of six years, among 172 patients diagnosed with vulvovaginal candidiasis, 13 women that presented RVVC and their partners were selected for this investigation. The isolates were obtained using Chromagar Candida medium, the species identification was performed by phenotypic and molecular methods and FLZ susceptibility was evaluated by E-test. Among 26 strains we identified 14 Candida albicans check for this species in other resources , six Candida duobushaemulonii, four Candida glabrata check for this species in other resources , and two Candida tropicalis check for this species in other resources . Agreement of the isolated species occurred in 100% of the couples. FLZ low susceptibility was observed for all isolates of C. duobushaemulonii (minimal inhibitory concentration values from 8-> 64 μg/mL), two C. glabrata isolates were FLZ-resistant and all C. albicans and C. tropicalis isolates were FLZ-susceptible. This report emphasises the importance of accurate identification of the fungal agents by a reliable molecular technique in RVVC episodes besides the lower antifungal susceptibility profile of this rare pathogen C. duobushaemulonii to FLZ.

Candida duobushaemulonii; recurrent vulvovaginal candidiasis; antifungal susceptibility testing

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