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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 111, No. 8, 2016, pp. 539-541
Bioline Code: oc16082
Full paper language: English
Document type: Short Communication
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 111, No. 8, 2016, pp. 539-541

 en Comparative genomic analysis of Brazilian Leptospira kirschneri check for this species in other resources serogroup Pomona serovar Mozdok
Moreno, Luisa Z.; Kremer, Frederico S.; Miraglia, Fabiana; Loureiro, Ana P.; Eslabao, Marcus R .; Dellagostin, Odir A.; Lilenbaum, Walter & Moreno, Andrea M.

Abstract

Leptospira kirschneri check for this species in other resources is one of the pathogenic species of the Leptospira check for this species in other resources genus. Human and animal infection from L. kirschneri gained further attention over the last few decades. Here we present the isolation and characterisation of Brazilian L. kirschneri serogroup Pomona serovar Mozdok strain M36/05 and the comparative genomic analysis with Brazilian human strain 61H. The M36/05 strain caused pulmonary hemorrhagic lesions in the hamster model, showing high virulence. The studied genomes presented high symmetrical identity and the in silico multilocus sequence typing analysis resulted in a new allelic profile (ST101) that so far has only been associated with the Brazilian L. kirschneri serogroup Pomona serovar Mozdok strains. Considering the environmental conditions and high genomic similarity observed between strains, we suggest the existence of a Brazilian L. kirschneri serogroup Pomona serovar Mozdok lineage that could represent a high public health risk; further studies are necessary to confirm the lineage significance and distribution.

Keywords
L. kirschneri; serovar Mozdok; genomics

 
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